icsg2000 title image
Oral Presentation

Novembe 2, 2000 (Thursday) (13:30-15:30)Session 1: Structural Genomics Projects (I)
(16:00-18:00)Session 2: Structural Genomics Projects (II)
Novembe 3, 2000 (Winsday) (9:00-10:20)Session 3: Structural Genomics Projects (III)
(10:40-12:00)Session 4: Structural Genomics Projects (IV)
(16:00-18:20)Session 5: Methodology
Novembe 4, 2000 (Thursday) (9:00-10:20)Session 6: Bioinformatics(I)
(10:40-12:00)Session 7: Bioinformatics(II)
(13:30-14:50)Session 8: Proteomics
(15:20-17:40)Session 9: NMR & X-ray Facilities
Novembe 5, 2000 (Thursday) (9:00-10:20)Session 10: Structural Biology(I)
(10:40-12:00)Session 11: Structural Biology(II)
(13:30-15:30)Session 12: Structural Biology(III)
(16:00-17:20)Session 13: Structural Biology(IV)



Session 1: Structural Genomics Projects (I)

13:30 Structural Genomics
Y. Nishimura; Graduate School of Integrated Science, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama, 236-0027 Japan; Genomic Sciences Center (GSC), The Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako-shi, Saitama, 351-0198 Japan
13:50 IGMS Support Programs for Structural Genomics
J. C. Norvell; National Institute of General Medical Sciences (NIGMS), National Institutes of Health (NIH), Bethesda, MD 20892-6200, USA
14:10 Completing the map of the protein universe
C. Sander; Whitehead Institute, MIT Center for Genome Research, Cambridge, MA, 02139, USA
14:30 The Protein Data Bank and Structural Genomics
H. M. Berman; Department of Chemistry, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854-8087 USA
14:50 Structural Genomics Projects and a New On-line Journal
Y. Arata;RIKEN Yokohama Institute, Suehiro-cho 1-7-22, Tsurumi, Yokohama 230-0045
15:10 Comparative and Evolutionary Genomics of Prokaryotes
H. P. Klenk, W. D. Leuschner, and K. Gellner; Gene and Genome Analysis Department, EPIDAUROS Biotechnologie AG




Session 2: Structural Genomics Projects (II)

16:00 Structure-based Inference of Molecular functions of "Hypothetical" Proteins
S.H.Kim; Universtiy of California and Lawrence Berkeley National Laboratory, Berkeley, CA. 94720, U.S.A.
16:20 Structural genomics: Foundation for the future of biology?
T. Terwilliger; Bioscience Division, Los Alamos National Laboratory, and the TB Structural Genomics Consortium
16:40 Structural and Functional Genomics of Extreme Thermophile, Thermus thermophilus HB8
S. Kuramitsu; Department of Biology, Graduate School of Science, Osaka University, and Harima Institute and Genomic Sciences Center (GSC), RIKEN, Japan
17:00 Structural Proteomics in Prokaryote Systems
A. M. Edwards, D. Christendat, A. Yee, C. Arrowsmith; Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada.
17:20 Structure-Based Functional Classification of Proteins for Structural Genomics
M. A. Kennedy, J. R. Cort, A. M. Edwards, C. H. Arrowsmith; Pacific Northwest National Laboratory, Richland WA 99352, USA
17:40 MEETING THE CHALLENGES OF HIGH-THROUGH STRUCTURE DETERMINATION FOR STRUCTURAL GENOMICS
B-C. Wang; Southeast Collaboratory for Structural Genomics, University of Georgia, Athens, Georgia 30602, U.S.A




Session 3: Structural Genomics Projects (III)

9:00 Protein Production for Structural Genomics
F. W. Studier, S. E. Gerchman, and D. Lin; Biology Department, Brookhaven National Laboratory
9:20 RIKEN Structural Genomics Initiative
S. Yokoyama; Genomic Sciences Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, RIKEN Harima Institute at SPring-8, 1-1-1 Kouto, Mikazuki-cho, Sayo, Hyogo 679-5148, and Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
9:40 The "Protein Structure Factory" - A Berlin-area Structural Genomics Project
U. Heinemann, K.P. Hofmann, G. Illing, C. Lang, H. Oschkinat, W. Sanger and M. Schroedter; Forschungsgruppe Kristallographie, Max-Delbruck-Centrum fur Molekulare Medizin, Robert-Rossle-Str. 10, D-13125 Berlin, Germany; Institut fur Chemie, Freie Universitat, Takustr. 6, D-14195 Berlin, Germany
10:00 Joint Center for Structural Genomics
I. Wilson;The Scripps Research Institute 10550 North Torrey Pines Road La Jolla, CA 92037 USA




Session 4: Structural Genomics Projects (IV)

10:40 Structure-based Functional Genomics
G.T. Montelione, S. Anderson, T. Acton, D. Palacios, B. Dixon, K. Gunsalus, Y. Huang, H. Moseley, D. Monleon, R. Paranji, G. V. T. Swapna, R. Tejero, R. Xiao, and Deyou Zheng; Center for Advanced Biotechnology Medicine, Rutgers University, Piscataway, NJ 08854
11:00 Rapid NMR Assignment of Proteins for Structural Genomics
T. Szyperski; Chemistry Department, State University of New York at Buffalo, NY, USA
11:20 Structural Genomics at the Biological Information Research Center
Y. Kyogoku; Fukui Institute of Science and Technology
11:40 RNA Structural genomics
G. Varani; MRC Laboratory of Molecular Biology Hills Road - Cambridge CB2 2QH - UK England




Session 5: Methodology

16:00 The High-Throughput Imperative in protein X-ray crystallography: final call for a unified Bayesian treatment of structure determination
G. Bricogne; Structural Studies Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom; LURE, Batiment 209D, 91405 Orsay, France.
16:20 Possible Artifacts in Protein Crystal Structures Introduced by Flash-Freezing
D. H. Juers and B. W. Matthews; Institute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, 1229 University of Oregon, Eugene, OR 97403-1229, USA
16:40 Protein modules - targets for structural genomics and beyond
I. D Campbell, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford, OX1 3QU, UK
17:00 Information transfer in proteins: combining crystallographic and genomic approaches
L. Moulinet, O. Poch, J.C. Thierry, D. Moras; UPR9004/CNRS, Laboratoire de Biologie et Genomique Structurales, IGBMC, 1, rue Laurent Fries, 67400 Illkirch, France.
17:20 Overexpression Vectors for the Study of Structural Genomics of Thermus thermophilus and Other Organisms with GC-rich DNA
M. Ishida, H. Funaki, M. Watahiki, and T. Oshima; Department of Molecular Biology, TokyoUniversity of Pharmacy and Life Science
17:40 A Novel Isotope Assisted Approach in Protein NMR Spectroscopy
M. Kainosho; Graduate School of Science, Tokyo Metropolitan University, 1-1 Minami-ohsawa, Hachioji, 192-0397 Tokyo, Japan
18:00 NMR and Structural Genomics
K. Wuthrich; Institut fur Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule, CH-8093 Zurich, Switzerland




Session 6: Bioinformatics (I)

9:00 Construction of a library of hidden Markov models of proteins of known strucutre and its use in the analysis of genome sequences
C. Chothia , J. Gough; MRC Laboratory of Molecular Biology, Hills Road Cambridge CB2 2QH England
9:20 Database analysis of ATP-binding proteins
N. Go, Department of Chemistry, Kyoto University
9:40 The fold rush - A statistical model for estimating the probability of new folds in the protein space
M. Linial and E. Portugaly; Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.
10:00 Protein Folds, Functions and Evolution
J. M. Thornton, A. Todd & Christine Orengo; University College and Birkbeck College, Biochemistry and Molecular Biology Department, University College, Gower Street, London WC1E 6BT, UK




Session 7: Bioinformatics (II)

10:40 Evolutionary Trace Annotation of Active Sites: From Structural to Functional Genomics
O. Lichtarge, A. Philippi, M. E. Sowa; Baylor College of Medicine, Molecular and Human Genetics Department, Program in Structural and Computational Biology and Molecular Biophysics
11:00 Clear correlation of exon-intron structure with protein module
M. Go; Division of Biological Science, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan
11:20 Computational Approaches for Structural Genomics
S. E. Brenner; Department of Plant & Microbial Biology, 111 Koshland Hall, University of California, Berkeley, 94720-3102, USA.
11:40 Informatics Approach to Identify Protein Functions from a New Molecular Surface Database, 'eF-site'
K. Kinoshita, J. Furui, and H. Nakamura; Institute for Protein Research, OsakaĦĦUniversity, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan




Session 8: Proteomics

13:30 Proteomics: High-Throughput Protein-Based Technologies For Solving Biological Problems
M. R. Wilkins; Proteome Systems Ltd, Locked Bag 2073, North Ryde NSW 1670, Sydney, Australia
13:50 Towards an understanding of mammalian proteomes through cDNA analysis: Comprehensive analysis of cDNAs encoding large proteins in the human brain
O. Ohara, R. Kikuno, and T. Nagase; Department of Human Gene Research, Kazusa DNA Research Institute
14:10 Functional Analysis of Proteins in Proteome Research
H. Hirano; Yokohama City University, Kihara Institute for Biological Research/Graduate School of Integrated Science
14:30 Using Yeast Protein Arrays for Functional Genomics
C. L. Tucker, P. Uetz, E. A. Brazeau, J. F. Gera, M. R. Martzen, E. J. Grayhack, Eric M. Phizicky, and Stanley Fields; Howard Hughes Medical Institute and Departments of Genetics and Medicine, University of Washington, Seattle WA 98195




Session 9: NMR & X-ray Facilities

15:20 Crystallography with Speed and Finesse
W. A. Hendrickson; Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032 USA
15:40 Present Status of Beamlines for Structural Biology at SPring-8
N. Kamiya; Division of Bio-Crystallography Technology, RIKEN Harima Institute / SPring-8
16:00 Automatic Weissenberg data collection system using SR for time-resolved protein crystallography to be opened in April 2001
N. Sakabe, K. Sakabe, T. Higashi, N. Igarashi, M. Suzuki, K. Sasaki; Foundation for Advancement of International Science, SBSP House, KEK-PF, Oho, Tsukuba, Ibaraki 305-0801
16:20 Midwest Center Structural Genomics for a Pilot Project
A. Joachimiak;Argonne National Laboratory, Argonne, IL. 60439, USA
16:40 Data Harvesting and Process Management in Protein Structure Determination
Z. Zolnai, P. Lee, J. Li, M. Chapman, B. F. Volkman, and J. L. Markley; National Magnetic Resonance Facility at Madison, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706 USA
17:00 NMR and Other Facilities in Genomic Sciences Center, RIKEN
H. Hirota; Genomic Sciences Center, RIKEN, Yokohama 230-0045, Japan
17:20 Attempts of high throughput structural characterization of paramagnetic metalloproteins by NMR
I. Bertini; Magnetic Resonance Center, University of Florence




Session 10: Structural Biology (I)

9:00 Domain identification and structure determination in transcription factors
P.E. Wright; Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
9:20 D. Rhodes
9:40 Structural Basis of Mini-F Replication Initiator Protein (RepE) and DNA Complex
K. Miki; Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan, and RIKEN Harima Institute / SPring-8, Koto 1-1-1, Mikazukicho, Sayo-gun, Hyogo 679-5148, Japan
10:00 Molecular Structures for Heteroduplex Joint-Formation in Homologous Genetic Recombination
T. Shibata, T. Nishinaka, Y. Ito, T. Mikawa, H. Aihara, H. Kurumizaka and S. Yokoyama; Cellular & Molecular Biology Laboratory, RIKEN; CREST JST,




Session 11: Structural Biology (II)

10:40 Crystallographic dessection of the spliceosomal snRNP Structures
K. Nagai, Y. Muto, D. P. Krummel, C. Kambach, S. Walke, R. Young, C. Oubridge, S. Price, P. Evans and J. Li; MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
11:00 Structures of RNA and RNA-Protein Complexes
J. Feigon, F.H.-T Allain, P. Bouvet, T. Dieckmann, L.D. Finger, and D.E. Gilbert; Department of Chemistry and Biochemistry,ĦĦUniversity of California, Los Angeles, California 90095-1569 79
11:20 Structure analysis of ribosomal proteins
I. Tanaka; Graduate School of Science, Hokkaido University
11:40 The structures of the enzymes of nitro-flavin oxidoreductase family
M. Tanokura, W-C Lee, H. Sasaki2, M. E. P. Murphy, K. Ito, M. Sakurai, M. Kamo, N. Kaneko, S. Zenno, and K. Saigo; Graduate School of Agricultural and Life Sciences, University of Tokyo




Session 12: Structural Biology (III)

13:30 Solution NMR Studies of Proteins and Protein Complexes Interactions
G. Wagner; Harvard Medical School, 240 Longwood Avenue, Boston, 240 Longwood Avenue, Boston, Massachusetts 02115 USA
13:50 Structure and function of Grb2
F. Inagaki, K. OguraĦ¤S. Yuzawa, M. Nishida, M. KawasakiĦ¤H. Hatanaka; Hokkaido University, CREST
14:10 Structural basis of inactivation of Rb tumor suppressor by SV40 large T antigen
H. Kim and Y. Cho; Department of Life Science, Pohang University of Science & Technology, Pohang, South Korea; Structural Biology Center, Korea Institute of Science & Technology, Seoul, South Korea
14:30 Three-Dimensional Structure and Function of Chromophores in Phycobiliproteins
D-C. Liang; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of science
14:50 Covalent linking of lac headpieces creates a strong DNA binding protein
R. Kaptein, C.G. Kalodimos, G. Folkers and R. Boelens; Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
15:10 NMR and crystallographic Studies of Macromolecular Complexes
I. Bosanac, H. Kurokawa, T. K. Mal, Y. Masutomi, K. Yap, T. Yuan, and M. Ikura; Division of Molecular and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON M5G 2M9, Canada




Session 13: Structural Biology (IV)

16:00 Three-dimensional structural view of ligand-receptor recognition
K. Morikawa and H. Jingami; Biomolecular Engineering Research Institute (BERI), 6-2-3 Furuedai, Suita, Osaka 565-0874, Japan
16:20 Crystal Structure of Bovine Rhodopsin
M. Miyano, T. Kumasaka, T. Hori, T. Okada, R. E. Stenkamp, K. Palczewski, and M. Yamamoto; Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Mikazuki-cho, Sayo-gun, Hyogo 679-5148, Japan.
16:40 NMR Approach to Membrane Proteins in Structural Genomics
H. Akutsu; Institute for Protein Research, Osaka University
17:00 Structure and function of a membrane protein complex, Bovine Heart Cytochrome c Oxidase
T. Tsukihara, E. Yamashita, T. Mizushima, K. Hirata, H. Aoyama, K. Muramoto, M. Odoko, R. Nakashima, K. Shinzawa-Itoh & S. Yoshikawa; Institute for Protein Research, Osaka University, Japan